SAMe(S-adenosyl-methionine) is an amino acid derivative used by your body in three important pathways:Methylation (contributing methyl groups to activate certain molecules)Synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)Trans - sulphuration (synthesis of cysteine, glutathione and other sulphate chemicals)SAMe occurs naturally in your body and is concentrated in the liver and brain. It is a major methyl donor in the synthesis of hormones, nucleic acids, proteins and phospholipids. SAMe is also required for the synthesis of norepinephrine, dopamine and serotonin, and plays a role in other intracellular metabolic pathways. SAMe facilitates glutathione usage and maintains acetylcholine levels. That, in turn, helps to enhance or maintain cognitive function and attenuate or prevent aggression of ageing and neurodegeneration. SAMe levels may decrease due to sickness and age. Its supplementation with the co-factors, folate, trimethylglycine (TMG or betaine), vitamins B6 and B12 appears to be an effective method to overcome this deficiency. There is evidence that SAMe assists in keeping cell membranes fluid and to make the neurotransmitter acetylcholine in your brain.Findings have proven the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects. SAMe addresses multiple problems that people face as they grow older, such as joint discomfort and immobilisation. In addition, it has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. When liver function is compromised, glutathione is depleted, which leads to free radical damage. IngredientsAmount Per Serving (1 enteric coated tablet): S-Adenosyl-Methionine 400 mg Other ingredients: cellulose, methacrylic acid copolymer, mannitol, citric acid, titanium dioxide, stearic acid, silica, hydroxypropyl methylcellulose, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, yellow ochre.Non-GMO Directions For UseTake one (1) tablet one to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. PrecautionsSAMe should not be taken by those diagnosed with bipolar disorder.Keep out of reach of children.Do not exceed recommended daily dose.Do not purchase if outer seal is broken or damaged.When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.Store tightly closed in a cool, dry place.